Research progress in calcium-modulating cyclophilin ligand
نویسندگان
چکیده
منابع مشابه
Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets a cellular calcium-modulating cyclophilin ligand to modulate intracellular calcium concentration and inhibit apoptosis.
On viral infection, infected cells can become the target of host immune responses or can go through a programmed cell death process, called apoptosis, as a defense mechanism to limit the ability of the virus to replicate. To prevent this, viruses have evolved elaborate mechanisms to subvert the apoptotic process. Here, we report the identification of a novel antiapoptotic K7 protein of Kaposi's...
متن کاملIdentification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation.
Angiotensin II (Ang II) plays a central role in cardiovascular physiology and disease. Ang II type I receptor (AT1) is thought to mediate most actions of Ang II. A novel AT1 receptor intracellular partner called AT1 receptor-associated protein (ATRAP) was identified, but its exact function has not been elucidated. A yeast two-hybrid screen using ATRAP as bait identified calcium-modulating cyclo...
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A cDNA clone, representing the mouse homologue of the recently described gene encoding the human calcium signal-modulating ligand, was isolated from a mouse thymus library. This clone exhibits extensive conservation of the primary nucleotide and deduced amino-acid sequences that, when considered with a similar secondary protein structure, transcript size and distribution of expression, suggests...
متن کاملInvolvement of Cyclophilin D and Calcium in Isoflurane-induced Preconditioning.
BACKGROUND The mitochondrial permeability transition pore (PTP) has been established as an important mediator of ischemia-reperfusion-induced cell death. The matrix protein cyclophilin D (CypD) is the best known regulator of PTP opening. Therefore, the authors hypothesized that isoflurane, by inhibiting the respiratory chain complex I, another regulator of PTP, might reinforce the myocardial pr...
متن کاملprogress of iran in medical research
the indexed iranian journals in isi and pubmed at the end of 2012 with known impact factor (if) were evaluated with regard to the number of articles published in 2010-2012, the number of citations by authors from inside and outside iran, their if as well as their ranking order among all other journals in their specialized categories. there were among 130 english journals, 21 indexed with known ...
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ژورنال
عنوان ژورنال: World Chinese Journal of Digestology
سال: 2007
ISSN: 2219-2859
DOI: 10.11569/wcjd.v15.i1.56